Shirley
                    
                    
                    
                    
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                        I would like to know if anyone has had  experience w/ rx's for Nephritis  recurrent, UTI's & Sepsis.  I have had  either sepsis or kidney infections 1-2 x's a yr requiring prolonged hospital stays & O/P IVAB's.  My kidney bx done 7 yrs ago showed mesangial & hereditary nephritis possible.  Is it possible to have lupus in the kidney get more severe over time.  I have been on Prednisone in varying doses from pulsed iv steroids of 1000 Gm to 40-60 Mg of Prednisone by mouth.  Whenever I wean down on the Prednisone I flare up.  I don't want to take any thing stronger than Methotrexate but as I'm getting sick all the time I'm unsure what course to take.  I was on a CD-4 Ligans protocol & ended up hospitalized for Enterococcal Sepsis.  I got warts & fungal nailss after this tx.  Any alternative tx's other than immune suppressives ???