leslie
                    
                    
                    
                    
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                        Do the days 16 - 25 in which I take take estrogen along with Premarin, sort of emulate "periods"?.  I do not refer to menstruating, but rather to the, for me, irritableness for no seeming reason.  Is this just my imagination or have there been studies or some documentation regarding others?  I just seemed so irritable recently and didn't really know why and then remembered how I was during my menstrual cycle, at least, according to those around me, such as my mother.  I concluded that my mood swing must have been due to the estrogen phase of my menopause regimen, rather like a "period".  Please inform if you have read or heard that  mood is affected during the 10-day period of estrogen with the regular hormone replacement.  My conjecture here my be totally wrong and there are other reasons for my moods. What do you know?