Brenda Thornton
                    
                    
                    
                    
                    
                    
                    
                        
                        
                        You would be utterly amazed by the number of physicians who will insist that a patient continue a medication in the presence of reactions such as hives.    Sometimes, I think they have mush for brains.  Ask the doctor to switch you to another anti-depressant.  It will involve weening you off Zoloft and bringing the dosage of the new drug up as the Zoloft is metabolized.      If the hives continue, then the hives could be a psychological reaction or due to something in the environment.