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Ecoli infection ( ecoli found in urine )

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Hi The ecoli bacteria was detected in my wifes urine culture.The percentage of this bacteria is very high,my wife is allergic to cipro and the doctor gave her bactrim ,the drug reacted initially but eventually became resistant to it.the docter tried a couple of other drugs but the same conditon prevails. The count is incresing and the docter is not able to contain it ...Please Advice what is to be done
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